Seen below are the RouteSolutions recommended installation settings for MapPoint 2010 for StreetSync v5:

Note:  The 'Previous Version Detected' frame will only appear if you have an existing version of MapPoint already installed on your machine.  It is required that you do NOT have or keep older versions of MapPoint on this machine when installing this application.  All versions other than the provided MapPoint version should be uninstalled prior to installing this application.